Hydrolysis of polysorbate in biopharmaceutical liquid formulations upon long-term storage represents a threat issue, since discount of the intact surfactant focus could compromise protein stability. Furthermore, accumulation of polysorbate degradation merchandise is related to the formation of particulates probably affecting drug product stability and high quality. These results are conventionally assessed by real-time end-of-shelf life research constituting an integral but prolonged strategy of formulation improvement. To speed up this process, we describe right here a robust device to conduct shake stress research primarily based on the managed hydrolysis of polysorbate 20 by beads-immobilized lipases. For this objective, the manufacturing of secure, partially degraded materials characterised by a consultant presence of non-emulsifying degradants comparable to ethoxylated sorbitan and free fatty acids was monitored by state-of-the-art chromatographic strategies making certain reasonable pharmaceutical circumstances.
Freeze-thaw, shaking and transport stress research of a mAb formulation didn’t solely exhibit that this method is helpful to find out the vital degradation stage impairing drug product high quality, however moreover revealed important variations in protecting results relying on the hydrolysis sample. As these outcomes emphasize, the outlined technique could assist formulation scientists to unveil the interrelationship between polysorbate hydrolysis merchandise and stabilization of the lively pharmaceutical ingredient in a holistic and time-saving method. Drug merchandise containing the antibiotics amoxicillin (500 mg as trihydrate) or doxycycline (200 mg as hyclate or monohydrate) with various qualitative excipient composition have been obtained from the German market and their biopharmaceutical properties have been characterised in compendial high quality management assessments, dissolution assessments run below BCS-based biowaiver circumstances and dissolution assessments utilizing biorelevant media.
Noticed variations in disintegration time and dissolution fee have been assessed in response to BCS-based biowaiver dissolution specs and in digital bioequivalence trials utilizing GastroPlus. Nice variation was noticed in dosage type efficiency, and two out of 5 drug merchandise for every lively ingredient didn’t exhibit in vitro similarity utilizing the BCS-based biowaiver specs, with coning being recognized as a key hindrance. Nonetheless, all drug merchandise investigated have been discovered to be equal in digital trials, concordant with their market approval standing, indicating that the present BCS-based biowaiver standards are over-discriminating. To bridge the hole between in vitro and pharmacokinetic evaluation of bioequivalence, modification of the experimental setup with using Peak Vessels and the validation of dissolution specs with digital bioequivalence trials seem like promising approaches. Nonetheless, neither method is at present foreseen by the harmonized ICH M9 BCS-based biowaiver steering.
Monitoring Modifications in Biopharmaceuticals: Toolbox for a Generic and Sturdy Excessive-Throughput Quantification Technique
Monoclonal antibodies (mAbs) represent one of the necessary and quickest rising sector inside the pharmaceutical trade. The number of totally different codecs and the massive molecule sizes of the mAbs end in an inherent complexity. As well as, the posttranslational modifications (PTMs) that may happen throughout manufacturing, formulation and storage pose a serious analytical problem for his or her characterization. These PTMs could have an effect on the protection, efficacy and/or pharmacokinetic profile of the medicinal product.
Due to this fact, strict high quality and stability monitoring, particularly of (probably) vital high quality attributes (CQAs), is necessary. Specializing in these wants, a toolbox for various approaches of peptide mapping within the routine high quality management (QC) surroundings was developed. This toolbox contains an automatic pattern preparation with an optimized buffer system together with a Single Quad LC-MS system, which gives the flexibleness to deal with a high-throughput workflow. Our outcomes exhibit {that a} Single Quad LC-MS system is appropriate for a routine work surroundings to observe modifications by utilizing a user-friendly system.
Present Applied sciences to Endotoxin Detection and Removing for Biopharmaceutical Purification.
Endotoxins are the foremost contributors to the pyrogenic response attributable to contaminated pharmaceutical merchandise, formulation elements, and medical gadgets. Recombinant biopharmaceutical merchandise are manufactured utilizing dwelling organisms, together with gram-negative micro organism. Upon the dying of a gram-negative bacterium, endotoxins (also called lipopolysaccharides; LPS) within the outer cell membrane are launched into the lysate the place they will work together with and type bonds with biomolecules, together with goal therapeutic compounds. Endotoxin contamination of biologic merchandise might also happen by water, uncooked supplies comparable to excipients, media, components, sera, gear, containers closure techniques, and expression techniques utilized in manufacturing.
 Polyclonal Goat anti-GST μ-form |
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| GST-ANTI-2 | Detroit R&D | 50 uL | EUR 280 |
 Polyclonal Goat anti-GST p-form |
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| GST-ANTI-3 | Detroit R&D | 50 uL | EUR 280 |
 Rabbit anti Pig Serum |
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| 40R-RS001 | Fitzgerald | 2 ml | EUR 241 |
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Description: Rabbit anti Pig Serum antibody |
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 anti-Serum Amyloid A |
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| YF-PA14498 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to Serum Amyloid A |
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anti-Serum Amyloid A |
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| YF-PA14499 | Abfrontier | 100 ug | EUR 403 |
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Description: Rabbit polyclonal to Serum Amyloid A |
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 anti-Serum Amyloid P |
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| YF-PA23225 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to Serum Amyloid P |
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anti-Serum Amyloid P |
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| YF-PA23226 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to Serum Amyloid P |
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anti-Serum Amyloid A |
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| YF-PA24655 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to Serum Amyloid A |
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anti-Serum Amyloid A |
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| YF-PA24656 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to Serum Amyloid A |
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 Goat anti Chicken Serum antibody |
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| 40-GC85 | Fitzgerald | 2 ml | EUR 265 |
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Description: Goat anti Chicken Serum antibody |
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 Rabbit anti Bovine Serum antibody |
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| 40R-RB001 | Fitzgerald | 2 ml | EUR 241 |
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Description: Rabbit anti Bovine Serum antibody |
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) anti-Human Serum Albumin (1G2) |
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| LF-MA0106 | Abfrontier | 100 ul | EUR 334 |
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Description: Mouse monoclonal to Human Serum Albumin |
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 Anti-Bovine Serum Albumin antibody |
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| STJ97128 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Rabbit polyclonal to Bovine Serum Albumin. |
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Anti-Bovine Serum Albumin antibody |
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| STJ97461 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to Bovine Serum Albumin. |
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 Anti-Human Serum Albumin antibody |
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| STJ99077 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to Human Serum Albumin. |
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Anti-Human Serum Albumin antibody |
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| STJ99078 | St John's Laboratory | 200 µl | EUR 197 |
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Description: Mouse monoclonal to Human Serum Albumin. |
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) Anti-Serum Amyloid P (4E8) |
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| YF-MA11946 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Amyloid P |
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) Anti-Serum Amyloid P (4F3) |
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| YF-MA11947 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Amyloid P |
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 anti-Serum Response Factor SRF |
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| YF-PA24768 | Abfrontier | 50 ul | EUR 334 |
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Description: Mouse polyclonal to Serum Response Factor SRF |
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 Rabbit Anti-Turkey Serum Albumin antiserum |
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| ALBT22-S | Alpha Diagnostics | 100 ul | EUR 469 |
 Goat Anti-Whole Serum polyclonal antibody |
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| CABT-BL8667 | Creative Diagnostics | 2.0 ml | EUR 325 |
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Goat Anti-Whole Serum polyclonal antibody |
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| CABT-BL8694 | Creative Diagnostics | 2.0 ml | EUR 325 |
 anti- Serum amyloid P component antibody |
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| FNab07756 | FN Test | 100µg | EUR 505.25 |
|
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Description: Antibody raised against Serum amyloid P component |
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anti- Serum amyloid P component antibody |
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| FNab07757 | FN Test | 100µg | EUR 505.25 |
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Description: Antibody raised against Serum amyloid P component |
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 Anti-Serum Amyloid P/APCS Antibody |
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| A00162 | BosterBio | 100ug/vial | EUR 334 |
 Anti-SAA4/Serum Amyloid A4 Antibody |
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| A07115 | BosterBio | 100ul | EUR 397 |
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Description: Rabbit Polyclonal SAA4/Serum Amyloid A4 Antibody. Validated in IHC and tested in Human. |
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, unlabeled) Rabbit Anti-Bovine IgG (serum), unlabeled |
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| 80517-AS-2 | Alpha Diagnostics | 1 mg | EUR 202 |
 antibody, rabbit serum) anti-RanBPM (human) antibody, rabbit serum |
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| 71-001 | Sceti | 50uL | EUR 401 |
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Description: The anti-RanBPM (human) antibody, rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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 antibody, rabbit serum) anti-RanBP2 (human) antibody, rabbit serum |
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| 71-003 | Sceti | 50uL | EUR 401 |
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Description: The anti-RanBP2 (human) antibody, rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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) Goat anti Human Serum antibody (Whole) |
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| 40-IG30 | Fitzgerald | 2 ml | EUR 314 |
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Description: Human Whole Serum antibody |
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 antibody, rabbit serum) anti-Rpn3 (yeast) antibody, rabbit serum |
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| 62-201 | Sceti | 100uL | EUR 453 |
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Description: The anti-Rpn3 (yeast) antibody, rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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 Anti-Streptolysin O antibody rabbit serum |
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| 64-001 | Sceti | 50uL | EUR 414 |
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Description: The Anti-Streptolysin O antibody rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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 antibody, rabbit serum) anti-Rad18 (human) antibody, rabbit serum |
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| 70-023 | Sceti | 50uL | EUR 414 |
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Description: The anti-Rad18 (human) antibody, rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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Anti-Serum Amyloid P/APCS Antibody |
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| PB9020 | BosterBio | 100ug/vial | EUR 334 |
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Anti-Serum Amyloid P/APCS Antibody |
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| PB9021 | BosterBio | 100ug/vial | EUR 334 |
 Anti-Serum amyloid P component antibody |
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| PAab07756 | Lifescience Market | 100 ug | EUR 355 |
) anti-Serum amyloid P component (6E6) |
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| LF-MA0160 | Abfrontier | 100 ul | EUR 334 |
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Description: Mouse monoclonal to Serum amyloid P component |
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 IgG) Goat Anti-Bovine Transferrin (serum) IgG |
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| TF19-A | Alpha Diagnostics | 1 ml | EUR 408 |
) Anti-Serum Response Factor SRF (2G2) |
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| YF-MA15601 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Response Factor SRF |
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) Anti-Serum Response Factor SRF (1C8) |
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| YF-MA15602 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Response Factor SRF |
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) Anti-Serum Response Factor SRF (1E1) |
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| YF-MA15603 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Response Factor SRF |
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) Anti-Serum Response Factor SRF (2C9) |
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| YF-MA15604 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Response Factor SRF |
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) Anti-Serum Response Factor SRF (4D2) |
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| YF-MA15605 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Response Factor SRF |
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) Anti-Serum Amyloid A (3C11-2C1) |
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| YF-MA10812 | Abfrontier | 100 ug | EUR 363 |
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Description: Mouse monoclonal to Serum Amyloid A |
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 Rabbit Anti-Chicken Serum Albumin protein antiserum |
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| ALBC15-S | Alpha Diagnostics | 100 ul | EUR 457 |
 Rabbit Anti-Hamster Serum Albumin protein antiserum |
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| ALBHS17-S | Alpha Diagnostics | 100 ul | EUR 457 |
 Serum Albumin, ascites) Monoclonal Anti-Monkey (Rhesus) Serum Albumin, ascites |
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| ALBMK22-M | Alpha Diagnostics | 100 ul | EUR 482 |
 Rabbit Anti-Sheep Serum Albumin protein antiserum |
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| ALBSH20-S | Alpha Diagnostics | 100 ul | EUR 457 |
 Mouse Monoclonal Anti-Turkey Serum Albumin IgG |
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| ALBST21-M | Alpha Diagnostics | 100 ul | EUR 482 |
 Goat Anti-Human serum C3b protein antiserum |
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| C3B12-S | Alpha Diagnostics | 100 ul | EUR 457 |
 Antibody) Human Anti Mouse Antibody Serum (HAMA) Antibody |
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| abx024169-1ml | Abbexa | 1 ml | EUR 342 |
|
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 Anti-Human Serum Albumin Antibody Fluorescein Conjugated |
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| A01245-2 | BosterBio | 1mg | EUR 1232 |
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Description: Rabbit Polyclonal Human Serum Albumin Antibody Fluorescein Conjugated. Validated in WB and tested in Human. |
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) Rabbit anti Whole Pig Serum (IgG fraction) |
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| 40R-RP001 | Fitzgerald | 20 mg | EUR 327 |
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Description: Affinity purified Rabbit polyclonal Rabbit anti Whole Pig Serum antibody (IgG fraction) |
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 antibody, rabbit serum) anti-Swi6 (fission yeast) antibody, rabbit serum |
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| 63-101 | Sceti | 50ul | EUR 375 |
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Description: The anti-Swi6 (fission yeast) antibody, rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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 antibody rabbit serum) Anti-NADase (hemolytic streptococcus) antibody rabbit serum |
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| 64-005 | Sceti | 50uL | EUR 414 |
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Description: The Anti-NADase (hemolytic streptococcus) antibody rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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 Mouse Anti Human Serum Albumin Monoclonal Antibody |
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| DMABT-49278MH | Creative Diagnostics | 0.2 mg | EUR 715 |
 Anti-Bovine Serum Albumin Rabbit Monoclonal Antibody |
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| M01245 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal Bovine Serum Albumin Antibody. Validated in IHC, WB and tested in Cow, Human, Mouse, Rat. |
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 Anti-Serum Amyloid A Rabbit Monoclonal Antibody |
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| M01362 | BosterBio | 100ug/vial | EUR 397 |
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Description: Rabbit Monoclonal Serum Amyloid A Antibody. Validated in WB and tested in Human. |
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 Equine Serum |
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| EQS001 | Neuromics | 500 ml | EUR 200 |
 Cow Serum |
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| abx098251-100ml | Abbexa | 100 ml | EUR 342 |
|
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 Fish Serum |
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| abx098257-10ml | Abbexa | 10 ml | EUR 439 |
|
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 Goat Serum |
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| abx098258-500ml | Abbexa | 500 ml | EUR 370 |
|
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Goat Serum |
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| abx098259-500ml | Abbexa | 500 ml | EUR 370 |
|
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 Horse Serum |
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| abx098260-100ml | Abbexa | 100 ml | EUR 342 |
|
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 Mouse Serum |
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| abx098261-100L | Abbexa | 100 L | EUR 129506 |
|
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Mouse Serum |
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| 20-abx098261 | Abbexa |
|
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Mouse Serum |
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| abx098261-5L | Abbexa | 5 L | EUR 8833 |
|
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Mouse Serum |
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| abx098262-1ml | Abbexa | 1 ml | EUR 1720 |
|
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 Porcine Serum |
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| abx098264-1L | Abbexa | 1 L | EUR 592 |
|
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 Rabbit Serum |
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| abx098265-100ml | Abbexa | 100 ml | EUR 272 |
|
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Rabbit Serum |
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| abx098266-500ml | Abbexa | 500 ml | EUR 481 |
|
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 Rat Serum |
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| abx098267-10ml | Abbexa | 10 ml | EUR 272 |
|
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 Sheep Serum |
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| abx098268-100ml | Abbexa | 100 ml | EUR 342 |
|
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 Canine Serum |
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| 88R-D005S | Fitzgerald | 50 ml | EUR 154 |
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Description: Non Sterile Canine Serum |
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Rabbit Serum |
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| 1267-1 | Biovision | EUR 157 | |
 Chicken Serum |
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| SER001 | Neuromics | 500 ml | EUR 265 |
 protein, ascites) Monoclonal Anti-Bovine Serum Albumin (BSA) protein, ascites |
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| ALBB11-M | Alpha Diagnostics | 100 ul | EUR 482 |
 protein antiserum) Goat Anti-Bovine Serum Albumin (BSA) protein antiserum |
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| ALBB12-S | Alpha Diagnostics | 100 ul | EUR 225 |
 protein IgG) Rabbit Anti-Bovine Serum Albumin (BSA) protein IgG |
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| ALBB14-A | Alpha Diagnostics | 1 mg | EUR 408 |
 Rabbit Anti-G. pig Serum Albumin protein antiserum |
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| ALBGP18-S | Alpha Diagnostics | 100 ul | EUR 457 |
 IgG1, ascites) Monoclonal Anti-Human serum albumin (HSA) IgG1, ascites |
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| ALBH14-M | Alpha Diagnostics | 100 ul | EUR 482 |
 Serum Albumin protein antiserum) Rabbit Anti-Monkey (Rhesus) Serum Albumin protein antiserum |
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| ALBMK21-S | Alpha Diagnostics | 100 ul | EUR 457 |
 Chicken Anti-Toxoplasma gondii IgG negative control serum |
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| AE-200180-01N | Alpha Diagnostics | 1 ml | EUR 164 |
 Chicken Anti-Toxoplasma gondii IgG positive control serum |
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| AE-200180-02P | Alpha Diagnostics | 1 ml | EUR 225 |
 Rabbit Anti-Pasteurella multocida antigens IgG -ve serum |
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| AE-310800-01N | Alpha Diagnostics | 1 ml | EUR 141 |
 Rabbit Anti-Pasteurella multocida antigens IgG +ve serum |
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| AE-310800-02P | Alpha Diagnostics | 1 ml | EUR 225 |
 Bovine Anti-Pasteurella multocida antigens IgG -ve serum |
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| AE-310810-05N | Alpha Diagnostics | 1 ml | EUR 141 |
 Bovine Anti-Pasteurella multocida antigens IgG +ve serum |
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| AE-310810-06P | Alpha Diagnostics | 1 ml | EUR 225 |
 Rabbit Anti-Pasteurella multocida toxin IgG -ve serum |
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| AE-310950-01N | Alpha Diagnostics | 1 ml | EUR 141 |
 Rabbit Anti-Pasteurella multocida toxin IgG +ve serum |
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| AE-310950-02P | Alpha Diagnostics | 1 ml | EUR 225 |
 Chicken Anti-Pasteurella multocida toxin IgG -ve serum |
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| AE-310955-03N | Alpha Diagnostics | 1 ml | EUR 141 |
 Chicken Anti-Pasteurella multocida toxin IgG +ve serum |
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| AE-310955-04P | Alpha Diagnostics | 1 ml | EUR 225 |
 Bovine Anti-Pasteurella multocida toxin IgG -ve serum |
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| AE-310960-05N | Alpha Diagnostics | 1 ml | EUR 141 |
 Bovine Anti-Pasteurella multocida toxin IgG +ve serum |
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| AE-310960-06P | Alpha Diagnostics | 1 ml | EUR 225 |
 protein IgG) Rabbit Anti-Fetal Bovine Serum (FBS) protein IgG |
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| FBS11-A | Alpha Diagnostics | 100 ul | EUR 408 |
 Antibody (HRP)) Goat Anti-Human Serum IgA (alpha) Antibody (HRP) |
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| abx023497-2ml | Abbexa | 2 ml | EUR 592 |
|
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 Mouse Anti-Sm antibody negative control serum, prediluted |
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| 5402 | Alpha Diagnostics | 1 ml | EUR 225 |
) Rabbit anti Whole Bovine serum antibody (IgG fraction) |
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| 40R-RB002 | Fitzgerald | 20 mg | EUR 327 |
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Description: Affinity purified Rabbit polyclonal Rabbit anti Whole Bovine serum antibody (IgG fraction) |
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 antibody rabbit serum) Anti-histone H2B (S. pombe) antibody rabbit serum |
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| 63-125 | Sceti | 50ul | EUR 375 |
|
Description: The Anti-histone H2B (S. pombe) antibody rabbit serum is available in Europe and for worldwide shipping via Gentaur. |
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 Goat anti-Human Serum IgA alpha Polyclonal Antibody |
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| DPAB1309GH | Creative Diagnostics | 2 ml | EUR 689 |
 Porcine Anti-PRRSV2-NP antibody negative control serum |
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| RV-400110-PNC | Alpha Diagnostics | 1 ml | EUR 164 |
 Porcine Anti-PRRSV1-NSP antibody negative control serum |
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| RV-400130-PNC | Alpha Diagnostics | 1 ml | EUR 164 |
 Porcine Anti-PRRSV1-NSP antibody positive control serum |
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| RV-400130-PPC | Alpha Diagnostics | 1 ml | EUR 225 |
 Porcine Anti-PRRSV2-NSP antibody negative control serum |
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| RV-400140-PNC | Alpha Diagnostics | 1 ml | EUR 164 |
 Porcine Anti-PRRSV2-NSP antibody positive control serum |
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| RV-400140-PPC | Alpha Diagnostics | 1 ml | EUR 225 |
 antiserum) Goat Anti-human Serum Amyloid A (SAA) antiserum |
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| SAA11-A | Alpha Diagnostics | 100 ul | EUR 482 |
 Swine Anti-Brucella abortus IgG positive control serum |
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| RB-500400-02P | Alpha Diagnostics | 1 ml | EUR 225 |
 Anti-Serum amyloid A protein antibody *Mouse anti-human, monoclonal IgG2b* |
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| V100140 | AAT Bioquest | 50 ug | EUR 306 |
|
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Anti-Serum amyloid A protein antibody *Mouse anti-human, monoclonal IgG2b* |
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| V100141 | AAT Bioquest | 1 mg | EUR 393 |
|
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 Reference serum) Mouse Serum Amyloid P Component (SAP) Reference serum |
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| SAP12-RS | Alpha Diagnostics | 100 ul | EUR 324 |
) Rabbit Serum (Sterile) |
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| 20-abx800002 | Abbexa |
|
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|
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Rabbit Serum (Sterile) |
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| abx800002-1L | Abbexa | 1 L | EUR 5437 |
|
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) Sheep Serum (Sterile) |
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| 20-abx800019 | Abbexa |
|
|
|
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Sheep Serum (Sterile) |
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| abx800019-1L | Abbexa | 1 L | EUR 996 |
|
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) Goat Serum (Sterile) |
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| 20-abx800034 | Abbexa |
|
|
|
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Goat Serum (Sterile) |
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| abx800034-1L | Abbexa | 1 L | EUR 926 |
|
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) Horse Serum (Sterile) |
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| 20-abx800049 | Abbexa |
|
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|
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Horse Serum (Sterile) |
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| abx800049-1L | Abbexa | 1 L | EUR 1316 |
|
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) Donkey Serum (Sterile) |
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| 20-abx800064 | Abbexa |
|
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|
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Donkey Serum (Sterile) |
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| abx800064-1L | Abbexa | 1 L | EUR 2221 |
|
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) Camel Serum (Sterile) |
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| 20-abx800079 | Abbexa |
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|
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Camel Serum (Sterile) |
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| abx800079-1L | Abbexa | 1 L | EUR 5924 |
|
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) Dog Serum (Sterile) |
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| 20-abx800109 | Abbexa |
|
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|
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Dog Serum (Sterile) |
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| abx800109-1L | Abbexa | 1 L | EUR 4935 |
|
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) Chicken Serum (Sterile) |
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| 20-abx800124 | Abbexa |
|
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|
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Chicken Serum (Sterile) |
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| abx800124-1L | Abbexa | 1 L | EUR 2583 |
|
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 Bovine Serum Albumin |
|||
| HY-D0842 | MedChemExpress | 10g | EUR 187 |
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Bovine Serum Albumin |
|||
| GE1877-100G | Glentham Life Sciences | 100 g | EUR 158 |
|
Bovine Serum Albumin |
|||
| GE1877-10G | Glentham Life Sciences | 10 g | EUR 54 |
|
Bovine Serum Albumin |
|||
| GE1877-250G | Glentham Life Sciences | 250 g | EUR 285 |
|
Bovine Serum Albumin |
|||
| GE1877-25G | Glentham Life Sciences | 25 g | EUR 70 |
|
Bovine Serum Albumin |
|||
| GE1877-500G | Glentham Life Sciences | 500 g | EUR 500 |
|
Bovine Serum Albumin |
|||
| GE1877-50G | Glentham Life Sciences | 50 g | EUR 102 |
 Newborn Calf Serum |
|||
| F0603-050 | GenDepot | 500ml | EUR 151 |
 Doner Horse Serum |
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| F0605-050 | GenDepot | 500ml | EUR 151 |
 Albumin Human Serum |
|||
| abx082261-250mg | Abbexa | 250 mg | EUR 203 |
|
|||
 Normal Bovine Serum |
|||
| abx098263-100ml | Abbexa | 100 ml | EUR 258 |
|
|||
 Serum Albumin Protein |
|||
| 20-abx263082 | Abbexa |
|
|
|
|||
|
Serum Albumin Protein |
|||
| abx263082-5gr | Abbexa | 5 gr | EUR 1066 |
|
|||
 Defibrinated Human Serum |
|||
| 90-1010 | Fitzgerald | 10 ml | EUR 127 |
|
Description: Defibrinated Human Serum for use in Controls |
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 Normal Goat Serum |
|||
| 9067 | Chondrex | 50 ml | EUR 100.75 |
|
Description: Normal Goat Serum |
|||
 Normal Human Serum |
|||
| 90R-1002 | Fitzgerald | 10 ml | EUR 254 |
|
Description: Normal Human Serum which has been lipid extracted and dialyzed against 10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
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 Steroid Free Serum |
|||
| 90R-1007 | Fitzgerald | 50 mL | EUR 392 |
|
Description: Steroid Free Human Serum |
|||
|
Normal Goat Serum |
|||
| 88-B9999G000-S0 | Fitzgerald | 10 ml | EUR 133 |
|
Description: Control Normal Goat serum |
|||
 Normal Canine Serum |
|||
| 88-NC25 | Fitzgerald | 100 ml | EUR 606 |
|
Description: Normal Canine Serum |
|||
 Normal Horse Serum |
|||
| 88-NE21 | Fitzgerald | 100 ml | EUR 30 |
|
Description: Control Normal Horse Serum |
|||
|
Normal Goat Serum |
|||
| 88-NG22 | Fitzgerald | 500 ml | EUR 30 |
|
Description: Control Normal Goat Serum |
|||
|
Normal Goat Serum |
|||
| 88-NG22S | Fitzgerald | 500 ml | EUR 191 |
|
Description: Control Normal Goat Serum |
|||
 Normal Mouse Serum |
|||
| 88-NM35 | Fitzgerald | 50 ml | EUR 516 |
|
Description: Normal Mouse Serum |
|||
 Normal Pig Serum |
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| 88-NP | Fitzgerald | 500 ml | EUR 243 |
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Description: Normal Pig Serum collected from pigs in the USA |
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 Normal Rabbit Serum |
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| 88-NR50 | Fitzgerald | 100 ml | EUR 150 |
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Description: Normal Rabbit Serum |
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 Normal Rat Serum |
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| 88-NR51 | Fitzgerald | 50 ml | EUR 599 |
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Description: Normal Rat Serum |
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 Normal Sheep Serum |
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| 88-NS55 | Fitzgerald | 100 ml | EUR 126 |
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Description: Normal Sheep Serum |
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Normal Mouse Serum |
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| 88R-1002 | Fitzgerald | 5 ml | EUR 203 |
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Description: Normal Mouse Serum which has been lipid extracted and dialyzed against 10 mM Sodium Phosphate, 0.15 M Sodium Chloride, pH 7.2 |
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The manufacturing course of is, due to this fact, in vital want of strategies to cut back and take away endotoxins by monitoring uncooked supplies and in-process intermediates at vital steps, along with ultimate drug product launch testing. This evaluate paper highlights a dialogue on three main matters about endotoxin detection strategies, upstream processes for the manufacturing of therapeutic molecules, and downstream processes to get rid of endotoxins throughout product purification. Lastly, we have now evaluated the effectiveness of endotoxin removing processes from a perspective of excessive purity and low price. This text is protected by copyright. All rights reserved.