HBV Seroconversion control Panel

HBV Seroconversion control Panel

The key shortcoming of nucleos(t)ide analogue remedy for power hepatitis B (CHB) is the frequent requirement for indefinite remedy.

Withdrawal of remedy can lead to viral rebound with an alanine aminotransferase (ALT) flare resulting in hepatic decompensation, whereas in others this may result in hepatitis B e antigen (HBeAg) seroconversion. The intention of the research was to establish host immune profiles related to these totally different outcomes.

Eighteen HBeAg(+) sufferers, enrolled on a part III trial with the nucleoside analogue adefovir dipivoxil, had been adopted for as much as 128 weeks. For the primary 48 weeks, all sufferers acquired steady remedy. Subsequently, sufferers skilled cycles of remedy interruptions as a consequence of random drug/placebo misallocations.

Host immune profiles had been characterised by measuring a panel of serum cytokines earlier than, throughout, and after every cycle of remedy withdrawal. Virus-specific T-cell responses had been additionally decided at these time factors in a subset of sufferers to elucidate the mechanisms utilized to management hepatitis B virus (HBV) replication post-treatment.

Considerably, elevated ranges of IFN-γ, IP-10, and IL-2 on-treatment had been related to HBeAg seroconversion after remedy withdrawal. In these sufferers, remedy interruption induced additional will increase in serum IFN-γ ranges and marked will increase in virus-specific T-cells producing IFN-γ, however minimal alterations in viremia and ALT.

In HBeAg(+) sufferers with low on-treatment ranges of serum IFN-γ, the interruption of remedy induced important elevations in HBV-DNA, ALT, IP-10, and will increase in virus-specific T-cells producing IL-10.

Evaluating on-treatment serum cytokines in live performance with virologic and medical parameters might assist to establish CHB sufferers who can efficiently discontinue nucleos(t)ide analogue remedy.

HBV Seroconversion Panel Donor# 65449 (9 X 1 mL)
HBV11000 9 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65449 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 65524 (8 X 1 mL)
HBV11001 8 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65524 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 65556 (6 X 1 mL)
HBV11002 6 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65556 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 65584 (8 X 1 mL)
HBV11003 8 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65584 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 65732 (8 X 1 mL)
HBV11004 8 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65732 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 65777 (14 X 1 mL)
HBV11005 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65777 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 66201 (17 X 1 mL)
HBV11006 17 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 66201 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 66537 (14 X 1 mL)
HBV11007 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 66537 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 67303 (18 X 1 mL)
HBV11008 18 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 67303 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 67449 (23 X 1 mL)
HBV11009 23 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 67449 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 67457 (18 X 1 mL)
HBV11010 18 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 67457 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 67694 (14 X 1 mL)
HBV11011 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 67694 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 67773 (6 X 1 mL)
HBV11012 6 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 67773 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 67962 (35 X 1 mL)
HBV11013 35 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 67962 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 68029 (12 X 1 mL)
HBV11014 12 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 68029 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 68105 (14 X 1 mL)
HBV11015 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 68105 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 68541 (10 X 1 mL)
HBV11016 10 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 68541 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 68739 (14 X 1 mL)
HBV11017 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 68739 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 70793 (14 X 1 mL)
HBV11024 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 70793 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 70970 (16 X 1 mL)
HBV11026 16 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 70970 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 71415 (13 X 1 mL)
HBV11027 13 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 71415 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 71840 (10 X 1 mL)
HBV11028 10 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 71840 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 69751 (13 X 1 mL)
HBV11029 13 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 69751 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 70292 (15 X 1 mL)
HBV11031 15 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 70292 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 72439 (13 X 1 mL)
HBV11052 13 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 72439 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 72474 (11 X 1 mL)
HBV11056 11 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 72474 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 71612 (8 X 1 mL)
HBV11058 8 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 71612 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 72324 (9 X 1 mL)
HBV11059 9 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 72324 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 71922 (11 X 1 mL)
HBV11062 11 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 71922 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 71782 (9 X 1 mL)
HBV11064 9 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 71782 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 73299 (15 X 1 mL)
HBV11069 15 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 73299 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 61248 (5 X 1 mL)
HBV6271 5 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 61248 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 61291 (25 X 1 mL)
HBV6272 25 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 61291 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 61042 (6 X 1 mL)
HBV6273 6 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 61042 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 61799 (7 X 1 mL)
HBV6274 7 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 61799 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 61066 (7 X 1 mL)
HBV6275 7 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 61066 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 60409 (8 X 1 mL)
HBV6276 8 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 60409 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63291 (11 X 1 mL)
HBV6277 11 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63291 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63426 (10 X 1 mL)
HBV6278 10 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63426 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63701 (7 X 1 mL)
HBV6279 7 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63701 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 61832 (5 X 1 mL)
HBV6280 5 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 61832 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 62433 (12 X 1 mL)
HBV6281 12 X 1 mL
EUR 1695.28
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 62433 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 62675 (14 X 1 mL)
HBV6282 14 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 62675 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 62825 (11 X 1 mL)
HBV6283 11 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 62825 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 62347 (19 X 1 mL)
HBV6284 19 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 62347 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 62967 (16 X 1 mL)
HBV6285 16 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 62967 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63133 (9 X 1 mL)
HBV6286 9 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63133 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63253 (11 X 1 mL)
HBV6287 11 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63253 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63568 (9 X 1 mL)
HBV6288 9 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63568 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63659 (10 X 1 mL)
HBV6289 10 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63659 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 63997 (12 X 1 mL)
HBV6290 12 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 63997 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 64121 (8 X 1 mL)
HBV6291 8 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 64121 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 64006 (12 X 1 mL)
HBV6292 12 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 64006 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 64132 (7 X 1 mL)
HBV6293 7 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 64132 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 66481 (17 X 1 mL)
HBV9072 17 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 66481 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 65099 (16 X 1 mL)
HBV9073 16 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 65099 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 66213 (20 X 1 mL)
HBV9074 20 X 1 mL
EUR 859.12
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 66213 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 1034644 (37 X 1 mL)
HBV9092 37 X 1 mL
EUR 2344.24
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 1034644 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 1087380 (31 X 1 mL)
HBV9093 31 X 1 mL
EUR 2344.24
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 1087380 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 74302 (17 X 1 mL)
HBV9098 17 X 1 mL
EUR 1129.52
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 74302 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV Seroconversion Panel Donor# 75255 (20 X 1 mL)
HBV9099 20 X 1 mL
EUR 1129.52
  • What is the product classification?
  • HBV Seroconversion Panel Donor# 75255 is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.
HBV LONGITUDINAL PANEL (12 X 1mL)
6504 12 X 1mL
EUR 1261.60
  • What is the product classification?
  • HBV LONGITUDINAL PANEL is marked as RUO.
Description: Please contact Gentaur in order to receive the datasheet of the product.

Identification of serum cytokine profiles related to HBeAg seroconversion following antiviral remedy interruption

The most important shortcoming of nucleos(t)ide analogue remedy for power hepatitis B (CHB) is the frequent requirement for indefinite remedy. Withdrawal of remedy can lead to viral rebound with an alanine aminotransferase (ALT) flare resulting in hepatic decompensation, whereas in others this may result in hepatitis B e antigen (HBeAg) seroconversion. The intention of the research was to establish host immune profiles related to these totally different outcomes.

Eighteen HBeAg(+) sufferers, enrolled on a part III trial with the nucleoside analogue adefovir dipivoxil, had been adopted for as much as 128 weeks. For the primary 48 weeks, all sufferers acquired steady remedy. Subsequently, sufferers skilled cycles of remedy interruptions as a consequence of random drug/placebo misallocations.

Host immune profiles had been characterised by measuring a panel of serum cytokines earlier than, throughout, and after every cycle of remedy withdrawal. Virus-specific T-cell responses had been additionally decided at these time factors in a subset of sufferers to elucidate the mechanisms utilized to management hepatitis B virus (HBV) replication post-treatment.

Considerably, elevated ranges of IFN-γ, IP-10, and IL-2 on-treatment had been related to HBeAg seroconversion after remedy withdrawal. In these sufferers, remedy interruption induced additional will increase in serum IFN-γ ranges and marked will increase in virus-specific T-cells producing IFN-γ, however minimal alterations in viremia and ALT.

by Tanish jain

In HBeAg(+) sufferers with low on-treatment ranges of serum IFN-γ, the interruption of remedy induced important elevations in HBV-DNA, ALT, IP-10, and will increase in virus-specific T-cells producing IL-10.

Evaluating on-treatment serum cytokines in live performance with virologic and medical parameters might assist to establish CHB sufferers who can efficiently discontinue nucleos(t)ide analogue remedy.